MMVSola Predictor

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Welcome to MMVSola!

Please, either

upload a Science Cloud input file, or
upload a MMVSola report file, or
specify parameters manually in the Prediction tab.

MMVSola version 1.5.1

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Active compound

Compound

Simulation parameters

Simulated Dose [mg]		Total Number of Doses		Dosing Interval [hr]

Chemical properties

LogD (or LogP for bases)

Molecular Weight [Da]

PK in vivo

	H		R		M		D
Fraction Absorbed (0 - 1)
Plasma Binding [%]
Blood to Plasma Ratio
Plasma CL [mL/min/kg]
Plasma Vss [L/kg]
Renal Plasma Clearance (mL/min/kg)

PK in heps

	H		R		M		D
Hep. Clint [µL/min/10^6 cells]
Measured fu in Hep. assay (0-1)
10^6 cells/mL in Hep. Assay
Hep. regression intercept
Hep. regression slope

PK in mics

	H		R		M		D
Mic. CLint [µL/min/mg]
Measured fu in Mic. assay (0-1)
mg/mL Protein in Mic. Assay
Mic. regression intercept
Mic. regression slope

PD in vitro

TCGLS 3D7 72h IC50 [nM]		Hill Slope		Log10 in-vitro PRR / 48h
Albumax Binding [%]		PRR Lag Time [hr]

PD in SCID

EC50 in SCID mouse blood [ng/mL]

Hill Slope in SCID

Clearance Prediction Method

IVIVE Allometry IVIVE + Allometry

MMVSola version 1.5.1

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Executive Summary

PK Prediction

Sensitivity Plots (slow generation)

Sensitivity Analysis (slow generation)

Science Cloud File

User Inputs

GPF in-vitro

GPF SCID

Comparative Executive Summary

Comparative PK Prediction

Comparative User Inputs

Additional Information

MMVSola version 1.5.1

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