MMVSola Predictor
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Prediction
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Welcome to MMVSola!
Please, either
upload a Science Cloud input file, or
uppload a MMVSola report file, or
specify parameters manually in the Prediction tab.
MMVSola version 1.3.0
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Compound
Simulation parameters
Simulated Dose [mg]
Total Number of Doses
Dosing Interval [hr]
Chemical properties
LogD (or LogP for bases)
Molecular Weight [Da]
PK in vivo
H
R
M
D
Fraction Absorbed (0 - 1)
Plasma Binding [%]
Blood to Plasma Ratio
Plasma CL [mL/min/kg]
Plasma Vss [L/kg]
Renal Plasma Clearance (mL/min/kg)
PK in heps
H
R
M
D
Hep. Clint [µL/min/10^6 cells]
Measured fu in Hep. assay (0-1)
10^6 cells/mL in Hep. Assay
Hep. regression intercept
Hep. regression slope
PK in mics
H
R
M
D
Mic. CLint [µL/min/mg]
Measured fu in Mic. assay (0-1)
mg/mL Protein in Mic. Assay
Mic. regression intercept
Mic. regression slope
PD in vitro
NF54 72h IC50 [nM]
Hill Slope
Log10 in-vitro PRR / 48h
Albumax Binding [%]
PRR Lag Time [hr]
PD in SCID
EC50 in SCID mouse blood [ng/mL]
Hill Slope in SCID
Clearance Prediction Method
IVIVE
Allometry
IVIVE + Allometry
Predict the Dose
MMVSola version 1.3.0
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